Virologic, Immunologic and Immunogenetic Correlates

RZHRG - Lab Work in the Field

This protocol focuses on the characteristics of the virus in the donor (originally HIV+) and recipient (originally HIV-) in heterosexual couples who have transmitted HIV; the genetic characteristics of the hosts as they relate to ‘contagion’, ‘vulnerability’ and ‘resistance’ to HIV infection and disease; and the immune responses that are associated with either transmission, or non-transmission despite many exposures.


• Approximately 25 million Africans are HIV+ and 225 million adults are HIV- and married, at risk of acquiring HIV within their marriages.

•The U.S. government spends $2.2 billion annually – 10 percent of the entire U.S. bilateral foreign aid budget -- to provide antiretroviral therapy to 3 million Africans.

•Treating one ART patient over the course of 10 years costs about $7000.

•The World Health Organization (WHO) estimates that five new people are infected by HIV for every two who receive antiretroviral therapy (ART).

Testing results from ZEHRP sites, January 2002 - June 2006. With 12,714 couples tested, 18% were found to be discordant.

Research at RZHRG